深圳大学西丽校区

学术讲座

【生命与海洋科学学院】学术讲座-Proteomics of neurodegenerative diseases

2019年05月06日

讲座题目: Proteomics of neurodegenerative diseases

主讲嘉宾:Ka Wan Li, 荷兰阿姆斯特丹自由大学分子与细胞神经生物学系

邀请人:沈立明 副教授

主持人:刘琼 教授

时 间:20190508日(星期三) 上午10:00

地 点:深圳大学西丽校区A6行政楼501会议室

讲座摘要:

Dementias pose major socio-medical burden, currently there is still  no cure. Novel proteomics approaches hold promise to identify alterations of the  brain proteome that could provide clues to the disease etiology. Here, we report  our proteomics findings on human post-mortem brains affected with (1)  Alzheimer’s Disease across Braak’s stages 0-6, and (2) their interaction with  ageing; (3) the analysis of  single cell types with granulovacuolar degeneration  versus cells with neurofibrillary tangles; and (4) AD tissues with capillary  cerebral amyloid angiopathy. We further studied (5) Frontotemporal Dementia with  mutations of C9orf72, MAPT or PGRN. Brain slices and single cells identified by  immunostaining were collected by laser-microdissection, and processed for  quantitative proteomics analysis by data dependent and data independent LC-MS/MS  analysis. These studies confirmed known cellular changes, and identified novel  proteins that may underlie distinct aspects of the diseases, some of which hold  promise to be developed as biomarker.

嘉宾简介:

Dr. Ka Wan Li currently works at the Department of  Neurosciences-CNCR, Vrije University Amsterdam. He is the group leader of  Neuroproteomics at Vrije University Amsterdam. Ka Wan does research in  Neuroscience. His current research focus on the characterization of protein  nano-machineries that underlies synapse function and plasticity, and study  synapse/tissue proteome changes in neurodegenerative and neuropsychiatric  disorders. State-of-the-art quantitative proteomics techniques are employed,  using both human post-mortem brain tissues from patients and healthy controls,  and the diverse mouse models of brain disorders.

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