深圳大学西丽校区

学术讲座

【医学部】学术讲座--Foxp3 Isoforms and Pathogenesis of Autoimmune Diseases

2019年03月20日

题  目: Foxp3 Isoforms and Pathogenesis of Autoimmune  Diseases

主讲嘉宾:Baohua Zhou, PhD

时  间: 2019321日(周四)上午10:00-12:00

地  点: 深圳大学医学部A7-551

主 持 人: 邢少军 教授

 

讲座内容:

Regulatory T (Treg) cells expressing the  X-chromosome-encoded transcription factor Foxp3 are a specialized lineage of CD4  T cells that provide a critical mechanism to suppress T cell responses to self,  the commensal microbiota, and dietary and environmental antigens. Lack or loss  of functional Foxp3 leads to wide spread autoimmunity and atopy caused by the  absence of Treg cells. Treg therapy and immunotherapy are promising approaches  to treat autoimmune disease and chronic allergic inflammation. While quite  effective in mouse studies, clinical studies on human diseases often give mixed,  or even limited, benefits .

Human and mouse FOXP3 genes are highly conserved in both  amino acid sequence and gene structure. However, the human FOXP3 gene encodes two major  alternatively spliced isoforms – a “full length” FOXP3 and a shorter isoform  lacking the region encoded by exon 2. The Foxp3 exon 2 region has been shown to  be important in regulating Th17 differentiation. For Treg development and  function, the two isoforms of FOXP3 were regarded as equally effective as forced  expression of either full-length or E2 isoform causes CD4+ T cells  to acquire Treg phenotypes and lose their cytokine-secreting capacity. However,  such studies using forced overexpression of FOXP3 isoforms in CD4 T cells are  likely not able to represent the real function of Tregs expressing these  isoforms at physiological levels. How Tregs expressing these two major isoforms  interact with other immune cells and function in vivo remains an enigma.

 

主讲嘉宾简介:

周保华教授,博士。2000年毕业于University of Washington,现在在 Indiana University School of Medicine, Department of  Pediatrics。周教授是美国免疫学学会会员,担任美国NIH课题评审、丹麦国家独立研究委员会课题评审等。近10年来,周教授发表论文20余篇,主要科研工作发表于Nature ImmunologyImmunityJournal of Allergy Clinical ImmunologyJournal of Immunology等。