深圳大学西丽校区

学术讲座

【医学部】学术讲座-- THE ROUTE TO ENGINEERED MEDICINES

2019年03月05日

主讲嘉宾: Kenneth A. Dawson  教授

    间: 201936日上午9:00-10:00

    点: 深圳大学西丽校区A2-517会议室

  要:

The lecture discuss the microscopic  molecular principles of organization at the nanoscale that may be used to  control and direct biological processes. Increasing understanding is emerging  about the detailed consequences of molecular organizations on the surface of  nanostructures and the role this has at cellular and organ (e.g. liver  clearance) immune and others. However, now the first detailed information is  also becoming available for the role of nanoscale shape, and the potential role  of shape in stimulating living systems.

The talk will stress the potential for a structured and rational  design approach, based on fundamental understanding to improve on current  phenomenological design approaches alone. Some considerations of scaling up, in  GLP-like conditions are given, and the potential for a these combined approaches  to lead to realistic therapies. We stress the potential to build a durable  science, with great potential impact, for the long term  .

 

主讲嘉宾简介:

 Prof Kenneth A. Dawson is  the Director of the Centre for Bio-Nano Interactions (CBNI) and Chair of  Physical Chemistry at University College Dublin. He has received several  international prizes, including the 2007 Cozzarelli prize from the National  Academy of Sciences USA, as well as IBM, Packard, Canon, Sloan and Dreyfus  prize, Harrison Medal of RSC, Lindemann Fellow. Prof Dawson is recognized as a  leading thinker on the principles governing the interactions of nanoscale  entities with living organisms, and implications for bio-nanoscience. He is the  founder of the modern conception and understanding of the ‘protein  (bio-molecular) corona’ responsible for the biological identity of engineered  nanoparticles. The ultimate goal of his research is to unravel the mechanisms  underlying the interactions between complex nanostructures and living systems  and to develop novel ways of using the nanoscale in precision diagnostics and  therapeutics.

His professional roles include acting as the coordinator  of the European Infrastructure in Nano safety, representing Ireland on various  international bodies, including the OECD and ISO working groups on standards for  Nanotechnology. He has been an advisor on nanoscience matters in the EU New Risk  Committee of the European Commission, as well as the Advisory Group of the  European Medicines Agency. Prof Dawson has experience in the management of  large-scale EU projects, including multi-sectoral cross-disciplinary research  projects and other international programs. He is Editor of Physica A, Associate  Editor of Journal of Nanoparticle Science, ACS Applied Biomaterials, ACS Nano  environmental, Scientific Reports and others as well as (from January) ACS  Nano.