深圳大学西丽校区

学术讲座

【医学部】学术讲座--Understanding Biological Recognition of Nanoparti

2019年03月05日

主讲嘉宾: Yan  Yan 教授

    间: 201936日上午10:00-11:00

    点: 深圳大学西丽校区A2-517会议室

    要:

Biomolecules  adsorbed on nanoparticles are known to confer a biological identity to  nanoparticles, mediating the interactions with cells and biological barriers.  Recently, there have been significant developments in understanding molecular  details of the bio-molecular corona, moving from macroscopic to microscopic,  primarily based on the immune-mapping technique. However, how these molecules  presented on the particle surface are connected with the biological recognition  in complex biological milieu remains unclear. To address it, we will present our  recent work focusing on the development of a robust in vitro platform to allow  direct identification of specific nanoparticle-receptor interactions. In this  presentation, we will give several examples of probing and connecting the  nanoparticle surface properties to their biological recognition using the in  vitro platform. We envisage that a purpose-built receptor library approach for  validating nanoparticle-receptor interactions will facilitate to unravel complex  biological processes in vivo.

 

主讲嘉宾简介:

Dr.  Yan Yan is an Assistant Professor in Biochemistry in School of Biomolecular and  Biomedical Science at University College Dublin (UCD). She received her PhD in  Biochemistry and Molecular Biology from Peking University, China. Afterwards Dr.  Yan pursued her postdoctoral training on targeted drug delivery in oncology at  University of Melbourne, Australia, and worked as a research fellow at  University of Melbourne before joining UCD in 2015.  

Dr.  Yan now is leading a research group in understanding how nanoscale interactions  can be used to reconstruct immune response with the aim of developing  immune-therapies. Dr. Yan has been a recipient of several prestigious  fellowships and awards, including 2017 the 1st place of outstanding early career  investigator team presentation at Interstellar Initiative awarded by the New  York Academy of Science and Japan Agency for Medical Research and Development,  2016 Science Foundation Ireland Starting Investigator Research Award, 2013  Australia Research Council Discovery Early Career Research Award, and 2013  Australian Eureka Prize for Excellence in Interdisciplinary Scientific Research.  She has co-authored over 50 publications in high profile  journals.