深圳大学西丽校区

学术讲座

【医学部】学术讲座—— From Molecule to Mammal: Inventing Luminescent N

2018年12月03日

主讲嘉宾: 韩纲 教授
时  间: 2018年12月5日下午2:00-4:00
地  点: 深圳大学西丽校区A2-517会议室
摘  要:
Functional luminescent nanoparticles are promising materials for in vitro and in vivo optical imaging and therapy due to their unique optical and chemical properties. In this talk, Professor Han will present a series of biocompatible luminescence nanoparticles. The first type of materials is upconversion nanoparticles (UCNPs). Prof. Han will present new developments regarding engineering UCNPs towards optogenetic applications in neuro-engineering and cancer immunotherapy. The second type of nanoparticles is persistent luminescence nanoparticles (PLNPs). They are bioluminescence-like and possess unprecedented in vivo deep tissue energy rechargeability, outstanding signal-to-noise-ratio with no need for an excitation resource (light) during imaging, and they can be directly detected with existing imaging systems. These nanoparticles continue to emit light for minutes or hours and, in some cases, days, after turning off the excitation source. These long-lasting, light-emitting nanocrystals can provide noninvasive imaging technology for evaluating structural and functional biological processes in living animals and patients. The third is a type of organic Biodpy nanoparticles that were tailored with outstanding NIR absorbing ability. Rather than the conventional laser light needed in PDT, Prof. Han will present their ultralow power lamp operable PDT applications in deep tissue tumor treatment. Finally, Prof. Han would like also to introduce a new organic upconversion system for in vivo anticancer release.
主讲嘉宾简介:
韩纲,University of Massachusetts-Medical School,生物化学与分子药理学系,副教授。南京大学化学专业本科和硕士,美国UMASS-Amherst分校化学系获博士学位,劳仑斯伯克利国家实验室分子工厂纳米中心博士后。主要在研方向是为:新颖纳米材料的光遗传学神经调控和免疫医学治疗以及面向临床转化的新颖分子成像应用,已在Nature, Nat Nanotech, Nat Communications, Elife, PNAS, Nano Letter, ACS Nano, JACS, Angew Chem, Advanced Materials, Small, 等杂志上发表了80余篇学术论文。很多工作被选作焦点文章,封面文章,或被媒体报道。获得伍斯特基金会梅尔·卡特勒奖、美国NIH “尤利卡”创新奖、HFSP人类前沿科学项目青年调查员奖、麻省大学医学院临床与转化科学奖项、Alex’s创新奖、受邀作为美国NIH 和国防部(DOD )专家评审,脑健康提案评审。担任Nat Mater, Nature Nano, Nano Letter, Angew Chem, JACS, Adv Mater等80余本杂志审稿人。所发表论文当前被SCI 期刊引用超过9400次。